PROS1 anticorps (AA 245-295) (HRP)

N° du produit ABIN1421026

Cet anticorps Lapin Polyclonal détecte spécifiquement PROS1 dans WB et IHC (p). Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour PROS1 anticorps (AA 245-295) (HRP) (ABIN1421026)

Antigène: PROS1 (PROS) (Protein S (PROS))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PROS1 est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PROS1 anticorps (HRP)

Épitope: AA 245-295

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Protein S/PROS

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PROS1

Antigène: PROS1 (PROS) (Protein S (PROS))

Autre désignation: Protein S

Sujet:

Synonyms: Preproprotein S, Propiece of latent protein S, PROS 1, PROS, PROS_HUMAN, PROS1, Protein S alpha, Protein Sa, PS 21, PS 22, PS 23, PS 24, PS 25, PS 26, PS21, PS22, PS23, PS24, PS25, PS26, PSA, Vitamin K dependent protein S, Vitamin K-dependent protein S.

Background: Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates clearance of early apoptotic cells. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP), 60-70 % of Protein S circulates in complex with C4BP. Calcium-dependent association of C4BP-Protein S with apoptotic cells influences the regulation of complement activation. Protein S has APC-independent anticoagulant activity through direct inhibition of prothrombin activation via interactions with Factor X A, Factor V A and phospholipids. Autosomal dominant Protein S deficiency (levels 15 to 37 % of normal) correlates with severe recurrent venous thrombosis.

ID gène: 5627

UniProt: P07225